Organoids recapitulate many aspects of tissue organization and cell composition and when derived from human stem cells provide the opportunity to study human diseases in a human context. The human brain displays unique aspects that cannot be adequately modeled in rodents, thus the use of human-derived cerebral organoids provides an opportunity to explore disease processes in this context.

We have established a highly efficient pipeline to generate morphologically similar cerebral organoids with consistent cell-type compositions as assessed by single-cell sequencing. Using this pipeline, our goal is to generate and provide cerebral organoids derived from stem cells to academic researchers to enable the application of state-of-the-art approaches for the study of human brain disorders.