My research is focused on understanding how extracellular cues regulate cell behaviour in development and cancer. We apply high throughput proteomic and functional genomic tools to map dynamic protein interactions and define their role in cell behaviour in cultured cells, organoids and mouse models. Of particular interest is how intersections between Wnt, TGFB and the Hippo pathways alters biological responses and contributes to disease.
Specific areas of investigation include:
Maintenance and induction of stem cell pluripotency
Control of stem cell fate, regeneration and cancer initiation in the intestinal crypt
The tumor microenvironment in cancer progression
Molecular basis of human bladder cancer
Analysis of single cell behavior in tissue morphogenesis and regeneration
Epithelial cell plasticity in development and cancer